Wobblers Paralysis| GREATDANELADY.COM

Introduction

I feel this is one of the best articles written on Wobblers Syndrome and want to share it with you. It is my understanding from talking to orthopedic vets that Wobblers Syndrome is a "condition" rather than a single cause disease. It can be cause by several factors: genetics, nutrition, metabolism, injury, trauma ...and poor structural design (engineering problems).

In 35 yrs of breeding Great Danes I have experienced genetic Wobblers, a direct link for 4 generations. I have witnessed nutritional induced wobblers with over-vitaminization, high calorie diets, uncontrolled portions, wobblers due to trauma to the neck from aggressive lead training at a very early age, and poor structure that causes undue trauma to the vertebra connections. In horses, there is a form of wobblers that is causes from herpes virus, this could also be a problem in dogs, no one has looked at it closley.

I have also know of considerable success in some cases with a change in diet, some anti-inflammatory supplements, acupuncture and chiropractic work. I personally would never put an animal through a mylogram - I know of too many animals that were worse off after the mylogram, likewise the surgery - to date anyway - it has a very low success rate, difficult to manage for recovery and very costly! You might find this information helpful to your situation:

Blackwatch Feed Program for Wobblers Syndrome

Now, in addition to the feed program there are some new supplements available that people are reporting with great success.

Use the addition of EZorb Calcium - a new breed of calcium that corrects bone metabolism. I have personally used this with great success on myself due to a fall/injury of my vertebra - it takes 6 weeks to feel results, but well worth the try and if you read about it, it is pretty amazing how it works.

http://www.elixirindustry.com/ezorb/

Second is a product called Recovery SA - again a new breed in nutriceuticals that function as medicine. I do know of two people that use this with great success. I believe one had a bit of a problem with loose stools..just watch for that and perhaps call and discuss it with the manufacturer - this is the wave of the future in controlling pain.

http://www.recoverysa.com/

This give you some good options and I do not see that they could not be used together.

Where to Find Alternative and Supportive Health Care Options

American Holistic Veterinarian Site for massage, chiropracter and acpuncture work.

I have had several people tell me that the Blackwatch Feed Program for Wobblers (kit#9) has really helped their dog.

With nutritional support along with gold bead implants by Dr. Terry Durkus of Marion, Indiana

your pet has a better chance of some quality of life. I know I personally would not go through the painful mylogram process nor the wobblers surgery. The experience I have had and with other breeders experiences, the success rates is horrific. I can't answer for small breeds, but for giant breeds, to me the surgery is not even an option due to the pain, after care and dismal success rate.

Permanent Acupuncture with Gold Bead Implants

Wobblers Syndrome by Dr. Bruce Wittles

It is my desire to provide an understanding of the total picture of proper nutrition and a well balanced and strong skeleton upon which these modern day giants are to support their massive bodies. If the foundation of any structure is weak, then the weight which is born by it will cause this foundation to break and fall. The principal breed affected with Wobbler's Syndrome is the Great Dane. Cervical Spondylopathy or Canine Wobblers Syndrome as the lay person knows it, consists of any
incoordination or lameness caused by pressure on the spinal cord as it travels through the neck (at any age for any reason).

In Great Danes, a true wobbler is usually seen between the ages of 3-12 months of age. The outstanding symptom is a slowly developing, progressive, incoordination and paralysis of the hind limbs. This paresis and/or incoordination is caused by pressure on the spinal cord as it passes thru the vertebrae of the neck, the last three being the most prominent sites. The animal may appear clumsy, "wobbling" or display swaying of the rear legs. On slick surfaces it may be difficult or impossible to walk. The dog may fall when attempting to turn and the toes of the hind feet may drag when walking. The dog usually has its legs spread out as far as possible trying to better balance itself. Initially front leg involvement is minimal or undetectable.

As the disease progresses, a characteristic short choppy rolling stride is seen on what appears to be somewhat rigid forelimbs. As the compression of the spinal cord becomes more severe, the front legs can have the same signs as the rear legs. There is usually little or no neck pain but the dog may stand with the neck flexed which usually alleviates some of the spinal cord pinching. Many dogs will object to neck manipulation and may even collapse when the movement is forced.

On occasion, there can be an acute onset of signs. They are usually more severe than with the progressive type. Forelimb involvement is usually present. There is also a higher incidence of neck pain with the acute onset. This type of wobblers is seen most frequently in five to seven year old Doberman Pinchers and is rarely seen in young Danes. This must be differentiated from similar signs caused by cervical disc protrusion or a fractured vertebrae.

The pressure of the spinal cord is due to improper formation of the anatomical parts surrounding the spinal cord during growth. The pressure can be due to one or a combination of the following:
weak ligaments - which hold the vertebral bodies in place - this allows irregular movement of the vertebral bodies as the neck is placed in various positions (subluxations) and causes a pinching of the spinal cord

hyperplasia of the yellow ligaments - normally these are thin loose elastic sheets located between the arches of adjacent vertebrae. Just beneath them is the small epidural space which is immediately above the spinal cord. With enlargement of these ligaments, the epidural space is obliterated and the yellow ligaments push directly on the spinal cord

malformation of the vertebrae - this can happen in various ways i.e
Assymetric cartilage defects which cause vertebral subluxations and Osteochondrosis of the articular facets which also lead to Stenosis (narrowing of the channel) of the cranial orifices of vertebral foramina which causes a pinching of the nervous system.
This is based on the breed, age, history and results of both a physical and neurological examination. Diagnosis is confirmed by radiographic examination.
A minimum of three views should be taken: a side view with the neck in normal position, a side view with the neck in a flexed position (head pointed towards the feet), and a side view with the head in a skyward position. A subluxation of one or more vertebrae may be the only causative agent and is often only seen when the neck is in and extended or flexed position. At times, a view of the neck from top to bottom must be taken.

A myelogram might be needed to properly determine the exact compression sites. Other disease entities which can cause similar symptoms that must be differentiated from are: disc protrusions, infectious, neoplastic, vascular, or traumatic disorders of the spinal cord. Other bone disorders common to the giant breeds can cause gait abnormalities but are usually presented with a lot of pain and do not show any nervous system involvement.

CAUSES
The exact reasons why the aforementioned vertebral abnormalities occur are unknown. There is probably a genetic factor that comes into play. This is determined by a high incidence of Canine Wobblers seen in certain families of Danes. It is difficult to separate the genetic from the environmental factor (nutrition, management and activity) as most of these families are kept in the same environments because many breeders keep the pups for three to four months thus keeping the family under a similar environment. Deformity and displacement of the cervical vertebrae secondary to a long neck, large head and rapid growth has been proposed. (Weight et al 1973

A vertebral canal that is too small for the diameter of the spinal cord could easily be caused by nutritional hypercalcitonism. As discussed in my second article, Nutrition of the Newly Born and Growing Individuals (GDR Jan/Feb '85). Calcitonin is released from the thyroid gland when the animal is fed a diet high in calcium. Its function is to retard bone reabsorption and thus decrease blood calcium levels. Remember, calcium is kept within strict limits in the blood stream. In normal growth, expansion of the spinal canal must be perfectly synchronized with growth of the spinal cord. Expansion is achieved by resorption of bone inside the vertebral canal. With hypercalcitonism, the retarded rate of bone resorption prevents proper expansion of the canal - therefore the diameter of the spinal canal is decreased and has an irregular contour. The spinal cord grows independently of the surrounding bone and is thus pinched by the nonresorbed bone therefore causing Cervical Spondylopathy.

Nerves leave the spinal cord, to go to other parts of the body, through spaces formed by notches is the vertebrae called foramina. A narrowness in these spaces will cause a pinching of the nerves leaving the spinal cord which in turn causes inflammation and swelling of the spinal cord itself thus causing wobblers syndrome. Hypercalcitonism causes narrowness in the vertebral canal can also yield a stenosis of the cranial orifices of the vertebral foramina due to its effect of slowing bone resorption. Hyper or overnutrition can also give the same results as an increased growth rate without proper mineralization and body controls can cause enlarged or asymmetric bone formation of the vertebrae in the neck as well as in any other bone in the body. This could easily result in pinching of the nerves as an overabundance of bone can yield improper notch formation. Although the vertebrae may not be as flexible as other joints in the body - they do move and have joint surfaces as do other bones. The joint surfaces called "articular facets" are lined with a cartilage the same as those of other joints. Improper formation of these surfaces can cause the vertebrae to move improperly and cause luxation or subluxation which can cause pinching of the spinal cord. A mechanism that can cause such a situation is Osteocondritis Dessecans (OCD). For now, let's describe OCD as a disturbance of endochondral ossification (one type of bone formation) which leaves the joint cartilage thicker than normal. It is therefore further away from the blood supply leaving it more susceptible to injury and cell death which will cause poor rotation of the joint and hence subluxation. This can happen at all or only one of the facets in the cervical spine. Again the last three vertebrae are most commonly affected. Osteochondrosis will be more thoroughly discussed in the next issue of the Reporter. The main cause of OCD is overnutrition or ad-lib feeding. Hedhammer et all (1974) studied the relation between overnutrition and skeletal disease in growing Great Danes. In general - dogs fed ad libitum had smaller than cervical vertebral foramina (notches) with subsequent spinal cord compression as well as asymmetric vertebral articular facets. There was also OCD in the facets displayed as defects in the cartilage covering the facets. They concluded that "excessive intake of food rich in protein, energy, calcium and phosphorous accelerates growth and can induce various skeletal changes including changes in the cervical vertebrae that result in the wobbler syndrome

TREATMENT

The treatment of cervical spondylopathy depends on the severity of the neurological involvement and the longevity of the disease process. Treatment is directed at stopping further cord trauma and at decreasing the current neurological deficits.
The acute form of canine wobbler syndrome is truly a medical emergency. The dog is very often quadriplegic and immediate veterinary attention must be sought in order for the spinal cord to be saved. Generally the veterinarian will treat the animal with diuretics (i.e. mannitol) and high dose steroids to decrease the swelling and inflammation in the cord as well as ascorbic acid to protect the myelin sheath that surrounds the nerves. This treatment may last as long as 2 to 3 days. Depending on the degree of improvement, decompressive surgery is usually required to prevent further trauma to the cord. If via rigorous medical treatment, the animal regains full neurological function, surgery may be delayed from one to three weeks with the animal probably kept in a neck brace. If, however, little or no improvement is rendered via medical care - surgery must be done within a few days in order to preserve the integrity of the spinal cord. The more time that passes with the spinal cord compressed and therefore without nutrients and oxygen, the higher the likelihood of some degree of permanent paralysis. The two most used surgical techniques are Dorsal Laminectomy (where the top of the spinal canal is removed thus allowing the spinal cord to rise out of the confining environment) and Ventral Decompression which removes ulcerated disc material as well as certain ligaments under the spinal cord and some of the vertebral body that may be compressing the cord. Choice of surgical technique is made by the orthopedic surgeon or by someone that has had much experience with spinal surgery as well as the special instrumentation needed for this complicated procedure. Even with the correct facilities and techniques there are always possibilities of post operative complications.

Dogs with slowly progressive signs of Wobblers Syndrome often respond well to a combination of cage rest and corticosteroid therapy. I usually apply a neck brace as well to provide some stabilization of the neck and at the same time some traction as well. This is only if the syndrome is caught in the early stages. Remember that the above will only alleviate the effects of compression of the cord and does not and will not correct the vertebral and ligamentous changes. The IMMEDIATE thing to do is to reduce the protein level of the diet. A protein level not to exceed 22-24% should be fed. Any and all mineral supplements should be discontinued. All food and water must be elevated to further reduce neck tension. Ball playing or any action where the head is dipped down to snatch up an object is to be eliminated. A very concerted effort to restrain this dog from exercise is to be instituted as this can easily yield an increase in the likelihood of vertebral subluxation or further damage to the spinal cord. It is a known fact that signs of joint instabilities are less severe in animals kept in a sedentary environment than those allowed unrestricted exercise. Hopefully if this is discovered early and the diet is changed while the bones are still forming and little recurrence of cord trauma occurs, the remaining formation of bone will be normal and the condition can stabilize itself to the point that surgery will not be needed. Surgery for the slowly progressive form of cervical spondylopathy may not be as rewarding as with the acute form, if it is discovered late since the damage to the spinal cord may be permanent. It may however, prevent further damage to the cord.

What can we do to prevent canine wobblers syndrome? My own observations and present studies indicate a probable genetic factor that may predispose certain lines or individuals to producing wobbler offspring. You as breeders must strongly consider the use of these lines or individuals for breeding purposes. You must answer to your own conscience and morals. The goal of breeders and the purpose of breeding is to strive to ever better the breed and those of you in breeding solely for the monetary gain must seriously reconsider this motive.

One thing that we all must do is to refrain from that archaic urge to supplement the excellent commercial foods available as the main cause of growing bone disparities in the giant breeds is hypernutrition.. For those of you who have found that one or two pups out of every litter or every other litter have shown signs or have developed into wobblers, I recommend that you do your very best to eliminate the environmental elements that might encourage or enhance the pups' chances of developing into a wobbler. This would entail feeding the entire litter the adult form of the high quality food (22%-24% protein) starting at weaning time. Don't use Iams puppy food or A.N.F. 30 for instance. The extra calcium and protein in these foods could easily cause signs of the above. I would feed a multiple vitamin and absolutely no additives. Perhaps a little canned food to increase the palatability. Each litter must be treated individually. Don't equivocate your litter to your friend's. Don't ignore the possibility that your dogs might be more efficient in digesting foods and utilizing a higher percentage of available nutrients than someone elses. This could give the same effect of overfeeding without the addition of any supplements. Periodic radiographs may be advantageous to early detection of wobbler development. Again it is very important to put as little stress on the necks of these pups - directions to be followed as previously described.

SUMMARY
There is no cut and dry answer or definition as to why or where this disease entity originates - this is a fairly new area of veterinary science. We are finding strong evidence suggestive to a genetic entity in this syndrome and have found definite proof that nutrition plays a major role in the development of wobblers and other bone disorders in the giant breeds. Again this is due to our wanting only the best for our dogs and knowing that the giant breeds need more nutrition than average dogs. Where we tend to go wrong is in the belief that if a little more is good, than a lot more must be better. Take an honest look at your own feeding program and look for areas where you might be able to improve the lives of your dog.

Neck Brace

Dr. Wittles talks about a neck brace. One excellent method to use is take a bath towel, one that is not an expensive thick one, or use one that is worn and thinner. Fold it in thirds the long way so it is about 8-9" deep. You can then wrap this around the dogs neck, not too tight, but with enough firmness that it will act as a brace. You can use duct tape or 2-3 diaper pins to hold it in place. This helps to stabilize the neck because they can't bend it too much from side to side and it does help. They will fight it at first, but soon realize it helps them to move around.

Also - if it means using some steroids to keep them comfortable, then do it. I am not a huge proponent of steroids, but they have a time and place and this is one of those. Nutritionally we can help with natural anti-inflammatory things like the Nzymes and MSM which I talk about in the feed program above.

At best all we can do is keep them comfortable and when the time comes when diet, acpuncture, massague, chiropractic work, supplements and steroids won't do it..then let them go in peace. When the quality of their life is compromised, you must let them go peacefully. Seek the advice of your vet on humane euthanusia. I offer two article to help you at this difficult time. Saying Good Bye and Starting Over.